Table of Contents
- 1 What is the reason for additional stability of DNA?
- 2 What confers additional stability to DNA?
- 3 Why does uracil make RNA unstable?
- 4 What are the 2 factors that confer stability to double helix structure of DNA?
- 5 Is thymine more stable than uracil?
- 6 Why does it make sense that tRNA and rRNA molecules are more stable than mRNA molecules?
- 7 Why does glycosylase not remove uracil from DNA?
- 8 Is there any evidence that RNA uses uracil as a substrate?
What is the reason for additional stability of DNA?
The presence of thymine at the place of uracil also confers additional stability to DNA.
What confers additional stability to DNA?
thymine
The presence of thymine at the place of uracil also confers additional stability to DNA.
What is the reason for the additional stability of DNA in comparison to RNA?
Due to its deoxyribose sugar, which contains one less oxygen-containing hydroxyl group, DNA is a more stable molecule than RNA, which is useful for a molecule which has the task of keeping genetic information safe. RNA, containing a ribose sugar, is more reactive than DNA and is not stable in alkaline conditions.
Why uracil is present in RNA instead of thymine?
The first three are the same as those found in DNA, but in RNA thymine is replaced by uracil as the base complementary to adenine. This base is also a pyrimidine and is very similar to thymine. Uracil is energetically less expensive to produce than thymine, which may account for its use in RNA.
Why does uracil make RNA unstable?
Unlike DNA, RNA in biological cells is predominantly a single-stranded molecule. This hydroxyl group make RNA less stable than DNA because it is more susceptible to hydrolysis. RNA contains the unmethylated form of the base thymine called uracil (U) (Figure 6), which gives the nucleotide uridine.
What are the 2 factors that confer stability to double helix structure of DNA?
Two factors are mainly responsible for the stability of the DNA double helix: base pairing between complementary strands and stacking between adjacent bases. By studying DNA molecules with solitary nicks and gaps we measure temperature and salt dependence of the stacking free energy of the DNA double helix.
Which confer stability of in addition to hydrogen bond for double helix?
The factors conferring stability to ds DNA: Base pair stacking i.e., the individual bases form a strong stacking interaction thereby providing stability to the double helix. Hydrogen bonds between the nitrogenous bases.
Is uracil more stable than thymine?
DNA uses thymine instead of uracil because thymine has greater resistance to photochemical mutation, making the genetic message more stable. This is necessary for holding all of the information needed for life to function.
Is thymine more stable than uracil?
DNA uses thymine instead of uracil because thymine has greater resistance to photochemical mutation, making the genetic message more stable. … Uracil is resistant to oxidation and is used in the RNA that must exist outside of the nucleus.
Why does it make sense that tRNA and rRNA molecules are more stable than mRNA molecules?
However, when RNA is in the form of a double helix (like in tRNA and lots of rRNA parts), it is limited in movement and the hydroxy group can’t as easily reach the phosphorus. For this reason, structure RNA molecules (in a double helix) are much more stable.
Why is thymine more stable than uracil?
Thymine is 5-methyuracil, the methyl group has a +I effect on the uracil ring, thereby conferring more stability to the compound, therefore it is more stable. Why is uracil present in RNA instead of thymine that’s present in DNA from which RNA was synthesized?
Why is thymine important to the stability of DNA?
In fact, the presence of thymine at the place of uracil also confers additional stability to DNA. (Detailed discussion about this requires understanding of the process of repair in DNA, and you will study these processes in higher classes.) Both DNA and RNA are able to mutate.
Why does glycosylase not remove uracil from DNA?
This glycosylase does not remove uracil residues from RNA or thymine residues from DNA. The capacity to distinguish thymine from uracil, the product of cytosine deamination necessary for the selective repair of the latter may be one reason why DNA evolved to contain thymine instead of uracil.
Is there any evidence that RNA uses uracil as a substrate?
Only a lot of circumstantial evidence. The inverse argument for DNA’s use of Thymine could also support RNA’s use of Uracil. In a competitive environment, a higher mutation rate afforded by the deamination of Cytosine to Uracil may have been an advantage to quickly promote change.