What is the benefit of micronization?

What is the benefit of micronization?

Improved bio-availability. Time-release engineering. Return to base particle size (post-lyophilization or spray-drying) Modify dissolution rates and solubility index.

What is micronization in pharmaceutical industry?

Micronization is the process of reducing the particle size of liquid pharmaceutical products using dynamic high pressure homogenization, to make a dispersion of the active ingredients much more stable for enhanced clinical effectiveness.

What does micronized mean in medication?

When a drug is said to be micronized, that means its particle size is generally less than 50 microns. When an API is micronized, its particle size is about 4 to 10 times smaller than conventional drug particles. Micronization technology has improved drug bioavailability in medicine ever since its discovery.

What is the difference between milling and micronization?

Using physical components to reduce the size of a given compound is called milling. Micronization means micronizing or reducing the size, whereas milling means crushing the particles for reducing their diameter. One can reduce the size of the particle by using milling in the range of micrometer and nanometer.

What is micronization API?

Micronization is a process for reducing the diameter of a solid material’s particles to enable the solubility of Active Pharmaceutical Ingredients (APIs). Whether administered orally or topically, this solubility is a key factor in bioavailability, and ultimately, the effectiveness of a drug.

What are nano suspensions?

[5] Nanosuspensions are submicron colloidal dispersions of nanosized drug particles stabilized by surfactants. [6] Nanosuspensions consist of the poorly water-soluble drug without any matrix material suspended in dispersion.

What is meant by micronization?

Definition of micronize transitive verb. : to pulverize especially into particles a few micrometers in diameter.

What is the difference between micronized and nanoparticles?

Nanoparticles are particles defined as less than 100 nanometers in diameter, or 0.1 micron. Typically micronized particles are between 0.1 micron and 100 microns, however the grinding process may result in nanoparticles called ‘fines’ which are smaller and in the nanoparticle range.

What is micronization process?

Micronization is the process of reducing the average diameter of a solid material’s particles. Traditional techniques for micronization focus on mechanical means, such as milling and grinding. These chemicals need to be micronized to increase efficacy.

Which type of mill is used in Micronisation of drugs?

Micronization can be performed with a jet mill or bead mill. Micronization, which reduces particles down to the micrometer or, in some cases, nanometer (1/1000 of a micrometer) size, can be used to improve the bioavailability of poorly soluble APIs by increasing particle surface area and accelerating dissolution rates.

Which of the following cosolvents can be used to increase the solubility of poorly soluble drugs?

Co-solvent solubilization approach has been used to enhance the solubility of seven antidiabetic drugs: gliclazide, glyburide, glipizide, glimepiride, repaglinide, pioglitazone, and roziglitazone.

How are nanoparticles used in medicine?

The nanoparticles are effective for drug delivery—the delivery of the medicine to the body—because they can very precisely find diseased cells and carry the medicine to them. This means that one can suffice with less dosage and thereby fewer side effects.