What happens to oxygen consumption if complex 1 is inhibited?

What happens to oxygen consumption if complex 1 is inhibited?

The inhibition of complex 1 decreases NADH oxidation, proton pumping across the inner mitochondrial membrane and oxygen consumption rate, resulting in lower proton gradient (Δψ) and reduction of proton-driven ATP synthesis from ADP and inorganic phosphate (Pi).

What will happen to a cell if you add an inhibitor of complex 1 of electron transport chain etc )?

If a chemical were added that inhibited the electron transport chain, the cell would no longer be able to fully oxidize glucose. Therefore, oxygen consumption will decrease.

What does Complex 1 do in the electron transport chain?

Complex I is a very large enzyme catalyzing the first step of the mitochondrial electron transport chain [1], [2]. The enzyme oxidizes NADH transferring electrons to Ubiquinone (Coenzyme Q, CoQ), a lipid soluble electron carrier embedded in the lipid bilayer of the inner mitochondrial membrane.

What does Complex 1 of mitochondria do?

Complex I is found in cell structures called mitochondria , which convert the energy from food into a form that cells can use. Complex I is the first of five mitochondrial complexes that carry out a multi-step process called oxidative phosphorylation , through which cells derive much of their energy.

What is an inhibitor of complex 1?

The best-known inhibitor of complex I is rotenone (commonly used as an organic pesticide). Rotenone and rotenoids are isoflavonoids occurring in several genera of tropical plants such as Antonia (Loganiaceae), Derris and Lonchocarpus (Faboideae, Fabaceae).

What would happen if complex I in the electron transport chain were nonfunctional?

Question: What would happen if Complex I in the electron transport chain were nonfunctional? Electrons would only be transferred from FADH2 and fewer protons would be pumped into the intermembrane space. The entire electron transport chain would stop functioning.

What is electron transport inhibitors?

Inhibitors are the inhibiting agents. They bind with the specific electron carriers. the carrier. The most important known inhibitors of the ETC are Amytal, Rotenone, Antimycin A, CO, Sodium Azide, and Cyanides.

What happens when complex II is inhibited?

Under conditions of high ATP, complex II is active, thus inhibiting complex I, and lowering H+/e−, leading to inefficient Ox-Phos. Alternatively, when ATP is low, complex II activity is also low, so more electrons enter at complex I, and H+/e− rises to meet the demand for more ATP [52].

What is the name of complex 1 in electron transport chain?

NADH oxidoreductase
Complex I of the electron transport chain, also known as NADH oxidoreductase or NADH dehydrogenase, is a very large, L-shaped structure that functions to accept high energy electrons from NADH molecules.

Which of the following is present in complex 1 in electron transport chain?

This complex, labeled I, is composed of flavin mononucleotide (FMN) and an iron-sulfur (Fe-S)-containing protein. FMN, which is derived from vitamin B2, also called riboflavin, is one of several prosthetic groups or co-factors in the electron transport chain.

What are inhibitors of electron transport chain?

Inhibitors of electron transfer chain Inhibitors of ETC are the one which interrupts the flow of electron through the respiratory chain and thus block the respiratory chain at 3 sites: complex-1, complex-3 and complex-4. This results in the blockage of proton pumping, ATP synthesis and oxygen uptake.