What causes Menetrier disease?

What causes Menetrier disease?

The exact cause of Menetrier disease is unknown. There may be multiple causes. In children, some cases of Menetrier disease may be associated with infection with cytomegalovirus (CMV). The bacterium Helicobacter pylori has been implicated in some adults with Menetrier disease.

How does Menetrier disease cause protein loss?

Ménétrier disease is a gastrointestinal condition characterized by overgrowth of the mucous cells (foveola) in the mucous membrane lining the stomach, causing enlarged gastric folds. This leads to excessive mucus production, causing protein loss from the stomach and low or absent levels of stomach acid.

What causes enlarged gastric folds?

Enlarged or giant gastric folds are due to diffuse mucosal hypertrophy, which may be due to a hyperplastic or nonhyperplastic gastropathy. Hyperplastic gastropathy – The gastric epithelial cells that compose the oxyntic glands become hyperplastic and give rise to giant mucosal folds.

Is Menetrier disease premalignant?

Ménétrier disease is a rare, acquired, premalignant disease of the stomach characterized by massive gastric folds, excessive mucous production with resultant protein loss, and little or no acid production.

How is Menetrier disease diagnosed?

However, a health care provider will confirm the diagnosis of Ménétrier’s disease through a computerized tomography (CT) scan, an upper GI endoscopy, and a biopsy of stomach tissue. A health care provider also may order blood tests to check for infection with H. pylori or CMV. Medical and family history.

What is the purpose for the rugae folds in the small intestine?

Function. A purpose of the gastric rugae is to allow for expansion of the stomach after the consumption of foods and liquids. This expansion result in greater surface area, thereby helpful in absorbing nutrients.

What is one disease that affects the digestive system?

Some common problems include heartburn, cancer, irritable bowel syndrome, and lactose intolerance. Other digestive diseases include: Gallstones, cholecystitis, and cholangitis. Rectal problems, such as anal fissure, hemorrhoids, proctitis, and rectal prolapse.

What are the stomach folds called and what do they secrete?

When the stomach is empty, and not distended, the lining is thrown up into folds called rugae. After eating, these folds flatten, and the stomach is able to distend greatly. The stomach has three anatomical regions: cardiac, which contains mucous secreting glands (called cardiac glands) and is closest to the oesophagus.

Which of the four layers help to form the gastric folds?

The outer layer of the stomach wall is smooth, continuous with the parietal peritoneum. The inner wall (mucosa and submucosa layers) is thrown into folds known as rugae, or gastric folds, which allow the stomach to distend upon the entry of the food.

What is fundus in the stomach?

Fundus: the upper part of the stomach next to the cardia. Body (corpus): the main part of the stomach, between the upper and lower parts.

What is leather bottle stomach?

Linitis plastica spreads to the muscles of the stomach wall and makes it thicker and more rigid. This means that the stomach can’t hold as much and doesn’t stretch or move as it should when you’re digesting food. This stiff walled stomach is sometimes called a leather bottle stomach.

What are rugae Where are they found and what is their function?

The stomach is an important organ in the digestive system that digests food and moves it into the small intestine. It has muscular walls as well as many folds and wrinkles called rugae as part of its inner layer.