Is modafinil safe for long term use?

Is modafinil safe for long term use?

The long-term safety of modafinil is not known. Modafinil affects an enzyme that may alter the blood concentration of some drugs such as opioids and some anti-viral medications. Check with your doctor for other drug interactions before taking modafinil.

How long does it take for modafinil to get out of your system?

Total clearance occurred in approximately 48-72 h with 2-5\% eliminated through urine as unchanged modafinil. The present study demonstrates that modafinil is detectable in the absence of hydrolysis and derivatization steps.

Can modafinil cause psychosis?

High dose of modafinil may induce positive psychotic symptoms similar with other stimulants such as amphetamine. The role of dopamine in positive psychotic symptoms is a well-known phenomenon.

Does modafinil affect serotonin levels?

Modafinil exhibits robust effects on catecholamines, serotonin, glutamate, gamma amino-butyric acid, orexin, and histamine systems in the brain. Many of these effects may be secondary to catecholamine effects, with some selectivity for cortical over subcortical sites of action.

Does modafinil affect serotonin?

Is modafinil bad for depression?

The analysis revealed that modafinil improved the severity of depression as well as remission rates. Modafinil also showed beneficial effects on fatigue and sleepiness, with the added benefit of the comparable side effects to placebo.

What happens if you take modafinil long term?

Whatever you learn while taking modafinil is unlikely to simply vanish from your memory. Mood improvement: It is well-established that long-term depression can detrimentally affect brain function, leading to cognitive deficits and increased risk of neurodegeneration.

Does modafinil interact with other medications?

Modafinil affects an enzyme that may alter the blood concentration of some drugs such as opioids and some anti-viral medications. Check with your doctor for other drug interactions before taking modafinil. NOTE: This is not a comprehensive safety evaluation or complete list of potentially harmful drug interactions.

Does modafinil improve cognitive performance in healthy individuals?

Modafinil may improve cognitive performance on complex tasks in healthy individuals, though no studies have examined it for long-term brain health. Our search identified: No studies have examined whether modafinil can prevent cognitive decline or dementia.

Is modafinil safe for Alzheimer’s patients?

One study reported that modafinil did not reduce apathy in Alzheimer’s patients [3]. Modafinil is generally considered safe for most people, with minor side effects such as headache, nausea, insomnia, anxiety, and dizziness. However, it may be associated with rare life-threatening skin conditions or rare psychiatric conditions [4] [5].