Is daratumumab an immunotherapy or chemo?

Is daratumumab an immunotherapy or chemo?

Darzalex contains daratumumab. This is a type of drug called a monoclonal antibody. Darzalex isn’t chemotherapy. It’s a type of targeted therapy and is sometimes called immunotherapy.

How long can you take daratumumab?

Official Answer. Darzalex is administered until signs of progression of multiple myeloma (MM) occur, or side effects become intolerable. Treatment durations of up to 25 months have been reported in clinical trials (range 0.1 month to 40.44 months).

What type of drug is daratumumab?

Daratumumab is in a class of medications called monoclonal antibodies. It works by helping the body to slow or stop the growth of cancer cells.

Is daratumumab an immunosuppressant?

“Daratumumab promotes T-cell expansion and activation, depletes immunosuppressive regulatory cells, and has multiple different mechanisms of action.” However, daratumumab is not the only immunomodulatory agent under investigation in multiple myeloma.

How effective is daratumumab?

Daratumumab, Lenalidomide, and Dexamethasone The overall response rate was 81\%, with 34\% of patients achieving a complete response or better and 63\% achieving a very good partial response (VGPR) or better. The median response duration was not reached, and 91\% of patients were free of disease progression at 12 months.

What are the side effects of daratumumab?

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• Bloating or swelling of the face, arms, hands, lower legs, or feet.
• chest pain or tightness.
• facial swelling.
• headache.
• puffiness or swelling of the eyelids or around the eyes, lips, or tongue.
• rapid, shallow breathing.
• skin rash, hives, or itching.
• slow or fast heartbeat.

What are the side effects of Daratumumab?

How effective is Daratumumab?

Does daratumumab affect immune system?

Once daratumumab attaches itself to the cells expressing CD38, it summons the body’s immune system to attack and destroy those cells.

Does Daratumumab cause neuropathy?

In this pooled safety population, the most common adverse reactions (≥20\%) were upper respiratory infection, neutropenia, infusion-related reactions, thrombocytopenia, diarrhea, constipation, anemia, peripheral sensory neuropathy, fatigue, peripheral edema, nausea, cough, pyrexia, dyspnea, and asthenia.

Does daratumumab cause neuropathy?

Does daratumumab make you tired?

The most common side effects of DARZALEX® include tiredness, nausea, diarrhea, constipation, vomiting, muscle spasms, joint pain, back pain, fever, chills, dizziness, trouble sleeping, cough, shortness of breath, swollen hands, ankles or feet, nerve damage causing tingling, numbness or pain, and cold-like symptoms ( …

Is daratumumab cytotoxic?

About Daratumumab. Daratumumab is an investigational human monoclonal antibody (mAb) with broad spectrum cytotoxic activity. It targets the CD38 molecule, which is highly expressed on the surface of multiple myeloma cells and may also have potential in other cancers on which CD38 is expressed.

Is mercaptopurine considered chemotherapy?

Drug type: Mercaptopurine is an anti-cancer (“antineoplastic” or “cytotoxic”) chemotherapy drug. This medication is classified as an “antimetabolite.”.

Why is doxorubicin used in chemotherapy?

Doxorubicin is a chemotherapy drug and is a treatment for many different types of cancer. Doxorubicin is a type of chemotherapy drug called an anthracycline. It slows or stops the growth of cancer cells by blocking an enzyme called topo isomerase 2. Cancer cells need this enzyme to divide and grow.