Table of Contents
- 1 How can you enhance the solubility of the drug?
- 2 What factors affect the solubility of a drug?
- 3 What is drug bioavailability?
- 4 How drug dissolution affect drug absorption?
- 5 Which one will be the easiest approach to enhance the solubility and dissolution of any drug?
- 6 Which of the following forms inclusion complex and improves aqueous solubility and dissolution rate?
How can you enhance the solubility of the drug?
Various techniques are used for the enhancement of the solubility of poorly soluble drugs which include physical and chemical modifications of drug and other methods like particle size reduction, crystal engineering, salt formation, solid dispersion, use of surfactant, complexation, and so forth.
What factors affect the solubility of a drug?
Drug solubility depends on the pH of fluid, temperature, volume, and contents of fluid. The lipophilicity of a drug is also correlated with water solubility. The rate and extent of absorption can be altered by food.
Which of the following is used in solid solution method of enhancing bioavailability?
10. Which of the following is used in solid solutions method of enhancing bioavailability? Explanation: There are three different ways of solid solutions these are the use of the solid solution, use of eutectic mixtures, and the use of solid dispersions.
What is drug bioavailability?
Bioavailability refers to the extent and rate at which the active moiety (drug or metabolite) enters systemic circulation, thereby accessing the site of action. Bioavailability of a drug is largely determined by the properties of the dosage form, which depend partly on its design and manufacture.
How drug dissolution affect drug absorption?
Because solid drug forms must dissolve before absorption can occur, dissolution rate determines availability of the drug for absorption. Dissolution, if slower than absorption, becomes the rate-limiting step.
Is one of the ways to increase dissolution rate through enhancement of solubility?
Particle Size Reduction The larger surface area allows greater interaction with the solvent which causes an increase in solubility. Conventional methods of particle size reduction, such as comminution and spray drying, rely upon mechanical stress to disaggregate the active compound.
Which one will be the easiest approach to enhance the solubility and dissolution of any drug?
Which one will be the easiest approach to enhance the solubility and dissolution of any drug? Explanation: Most drugs are weak acids or weak base3s. Thus, one of the easiest approaches to enhance the solubility and dissolution of any drug is to convert them into their salt forms.
Which of the following forms inclusion complex and improves aqueous solubility and dissolution rate?
| Q. | Which of the following forms inclusion complex and improves aqueous solubility and dissolution rate? |
|---|---|
| B. | PEG |
| C. | PVT |
| D. | Poloxamer |
| Answer» a. Cyclodextrins |
What is total systemic clearance Mcq?
Explanation: The sum of individual clearances by all eliminating organs is called total body clearance or total systemic clearance. It is expressed as the sum of renal and non-renal clearance. This term is applied to all organs involved in drug elimination.